Macrophage Infection via Selective Capture of HIV-1-Infected CD4+ T Cells

نویسندگان

  • Amy E. Baxter
  • Rebecca A. Russell
  • Christopher J.A. Duncan
  • Michael D. Moore
  • Christian B. Willberg
  • Jose L. Pablos
  • Andrés Finzi
  • Daniel E. Kaufmann
  • Christina Ochsenbauer
  • John C. Kappes
  • Fedde Groot
  • Quentin J. Sattentau
چکیده

Macrophages contribute to HIV-1 pathogenesis by forming a viral reservoir and mediating neurological disorders. Cell-free HIV-1 infection of macrophages is inefficient, in part due to low plasma membrane expression of viral entry receptors. We find that macrophages selectively capture and engulf HIV-1-infected CD4+ T cells leading to efficient macrophage infection. Infected T cells, both healthy and dead or dying, were taken up through viral envelope glycoprotein-receptor-independent interactions, implying a mechanism distinct from conventional virological synapse formation. Macrophages infected by this cell-to-cell route were highly permissive for both CCR5-using macrophage-tropic and otherwise weakly macrophage-tropic transmitted/founder viruses but restrictive for nonmacrophage-tropic CXCR4-using virus. These results have implications for establishment of the macrophage reservoir and HIV-1 dissemination in vivo.

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عنوان ژورنال:

دوره 16  شماره 

صفحات  -

تاریخ انتشار 2014